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Canine gene

CNGB1

Human counterpart: CNGB1

CNGB1 is a gene catalogued in the canine genome. Below are the inherited conditions OMIA links to it in dogs, its human counterpart, and its canonical records across the genomics world.

Conditions linked to this gene

The inherited conditions OMIA associates with CNGB1 in dogs. Each links to the full record.

In the reference databases

CNGB1 as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.

The human counterpart

In humans, this gene's counterpart is CNGB1. That ortholog is what connects CNGB1 to a century of human medical genetics. The dog and human proteins are 74% identical.

In people, CNGB1 appears tolerant of loss-of-function variation (gnomAD v4.1 constraint, LOEUF 0.94). Constraint measures intolerance to loss-of-function only and does not indicate importance; some tolerant genes cause disease through other mechanisms.

In people, variants in the CNGB1 gene have conflicting classifications in ClinVar, and none is expert-reviewed. The evidence is unsettled, not that variants here are benign.

In dogs, 34 of 1,891 Dog10K variants in this gene sit at a position kept conserved across 241 mammals (the exhaustive scan), candidates worth a closer look, never a diagnosis.

Translational evidence balance
dog-ahead (unaudited) · +1

The dog side carries more cited disease evidence than the human side. This is unaudited: it can mean the dog literature is genuinely ahead, or that our human ingestion is still incomplete. It is a lead to check, not a conclusion. Coverage, not importance. D = 1 dog vs H = 0 human cited disease channels.

Medicine face

Q2 · canine filled, medicine dark

CNGB1

Two planes on one gene. Disagreement is the reading, not a hole to fill.A characterized canine model. We hold no labeled human product on this target.

Canine plane

Coverage

dark · below bar

lit_any

Spectra

4 named streams agree. A recount, not a medicine vote.

Open Spectra

Lookup · Discovery · Frontier

Lookup cleared (human P/LP signal exists below the 3-star expert-review bar; moderate-confidence anchor (Landrum et al. 2018)). Discovery recovered known. A candidate never fills a drug row. Frontier cause below bar.

Medicine plane

Mechanism

Pore-forming subunit of the rod cyclic nucleotide-gated channel.

Full function description, 9 more sentences
  • Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals.
  • In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals.
  • Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade (By similarity).
  • Pore- forming subunit of the olfactory cyclic nucleotide-gated channel.
  • Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal.
  • Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization.
  • The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants (By similarity).
  • Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations.
  • The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels (By similarity).

Source UniProt via Open Targets · PMID 34699778

Activation of the phototransduction cascade · Inactivation, recovery and regulation of the phototransduction cascade · Olfactory Signaling Pathway · VxPx cargo-targeting to cilium · Reactome

Molecules

We hold no labeled human product and no Open Targets approval row for this target.

Canine trials

unqueryable

We hold no canine registry row. The AVMA Veterinary Clinical Trials Registry is the index that would hold one. This station is unqueryable until that ingest exists. That is not evidence that nobody runs trials in dogs.

PK / tox station

stub

This station is not wired. No PK or tox numbers.

This is not a treatment recommendation and not a claim about any individual dog.

Molecule direction and mechanism of action include ChEMBL (CC BY-SA 3.0).

Coverage · Spectra · Frontier

Research tools for this gene
Dog10K lookup Candidate models AVCG classification table

Lookup and discovery are candidate-framed research surfaces. Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.

On the numbers

Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For CNGB1 we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.

How to cite this page

Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.

Last updated
Sources: OMIA · Sniff gene crossrefs · Ensembl / NCBI / HGNC · gnomAD v4.1 (Karczewski 2020) · ClinVar (Landrum 2018) · Dog10K (Meadows 2023) · Zoonomia 241-way phyloP (Christmas 2023)