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Canine gene

F9

Human counterpart: F9

F9 is a gene catalogued in the canine genome. Below are the inherited conditions OMIA links to it in dogs, its human counterpart, and its canonical records across the genomics world.

Conditions linked to this gene

The inherited conditions OMIA associates with F9 in dogs. Each links to the full record.

In the reference databases

F9 as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.

The human counterpart

In humans, this gene's counterpart is F9. That ortholog is what connects F9 to a century of human medical genetics. The dog and human proteins are 85% identical (a lower-confidence 1:1 call, shown for transparency, not hidden).

In people, variants in the F9 gene are classified as pathogenic in ClinVar for 1 expert-reviewed condition.

Translational evidence balance
balanced · 0

Dog and human evidence are symmetric here, a validated cross-species footprint. Coverage, not importance. D = 1 dog vs H = 1 human cited disease channels.

Medicine face

Q1 · both planes filled

F9

Two planes on one gene. Disagreement is the reading, not a hole to fill.A teaching case. Both the canine evidence plane and the human medicine plane hold a row.

Canine plane

Coverage

answered

lit_all

Spectra

6 named streams agree. A recount, not a medicine vote.

Open Spectra

Lookup · Discovery · Frontier

Lookup abstained. Discovery recovered known. A candidate never fills a drug row. Frontier is not the subject here.

Medicine plane

Mechanism

Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.

Source UniProt via Open Targets · PMID 8295821 · PMID 2592373 · PMID 20121197 · PMID 20121198 · PMID 1730085 · PMID 19846852 · PMID 39880037

Protein hydroxylation · Initiation of coagulation cascade · Defective F9 secretion · Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus · Removal of aminoterminal propeptides from gamma-carboxylated proteins · Defective factor IX causes thrombophilia · Reactome

Molecules

  • Beqvez, generically Fidanacogene Elaparvovec

    APPROVAL

    EXOGENOUS GENE · Action on the human target as recorded by the cited medicine-plane source. Not a canine treatment claim and not a disease-direction claim.

    Labeled for hemophilia B.

  • Idelvion, generically Albutrepenonacog Alfa

    APPROVAL

    EXOGENOUS PROTEIN · Action on the human target as recorded by the cited medicine-plane source. Not a canine treatment claim and not a disease-direction claim.

    Labeled for hemophilia B.

  • Coagulation Factor Ix Human

    APPROVAL

    EXOGENOUS PROTEIN · Action on the human target as recorded by the cited medicine-plane source. Not a canine treatment claim and not a disease-direction claim.

    Labeled for hemophilia B.

  • Benefix, generically Coagulation Factor Ix Recombinant Human

    APPROVAL

    EXOGENOUS PROTEIN · Action on the human target as recorded by the cited medicine-plane source. Not a canine treatment claim and not a disease-direction claim.

    Labeled for hemophilia B.

Emicizumab, Pegnivacogin and Prothrombin Complex Concentrate and 2 more act on this protein and are labeled for other conditions. Acting on a protein is not treating a disease of it.

More molecule rows are held. This face does not print an approved-drug count.

Canine trials

unqueryable

We hold no canine registry row. The AVMA Veterinary Clinical Trials Registry is the index that would hold one. This station is unqueryable until that ingest exists. That is not evidence that nobody runs trials in dogs.

PK / tox station

stub

This station is not wired. No PK or tox numbers.

This is not a treatment recommendation and not a claim about any individual dog.

Molecule direction and mechanism of action include ChEMBL (CC BY-SA 3.0).

Coverage · Spectra · Frontier

Research tools for this gene
Dog10K lookup Candidate models AVCG classification table

Lookup and discovery are candidate-framed research surfaces. Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.

On the numbers

Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For F9 we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.

How to cite this page

Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.

Last updated
Sources: OMIA · Sniff gene crossrefs · Ensembl / NCBI / HGNC · ClinVar (Landrum 2018)