RSPO2
RSPO2 is a gene catalogued in the canine genome. Here is its canonical identity across the genomics world and, where documented, its human counterpart.
RSPO2 is the furnishings gene that produces the eyebrows-and-mustache pattern of Wheatens, Schnauzers, and Wire-haired terriers.
The atlas reads this gene through one marker. The atlas has too few dogs of breeds that visibly have and lack the trait to check it, so this page shows no breed frequencies for it.
RSPO2 as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.
In humans, this gene's counterpart is RSPO2. That ortholog is what connects RSPO2 to a century of human medical genetics. The dog and human proteins are 85% identical.
In people, RSPO2 appears tolerant of loss-of-function variation (gnomAD v4.1 constraint, LOEUF 0.67). Constraint measures intolerance to loss-of-function only and does not indicate importance; some tolerant genes cause disease through other mechanisms.
In people, variants in the RSPO2 gene are reported as pathogenic in ClinVar but not yet at our 3★ expert-panel bar (criteria-provided submissions can exist without expert-panel review). The evidence is limited, not that variants here are benign.
In dogs, 36 of 3,869 Dog10K variants in this gene sit at a position kept conserved across 241 mammals (the exhaustive scan), candidates worth a closer look, never a diagnosis.
The dog side carries more cited disease evidence than the human side. This is unaudited: it can mean the dog literature is genuinely ahead, or that our human ingestion is still incomplete. It is a lead to check, not a conclusion. Coverage, not importance. D = 1 dog vs H = 0 human cited disease channels.
Lookup and discovery are candidate-framed research surfaces. Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.
Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For RSPO2 we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.
Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.