STC2
STC2 is a gene catalogued in the canine genome. Here is its canonical identity across the genomics world and, where documented, its human counterpart.
STC2 is a stanniocalcin locus modulating growth-axis signaling.
The atlas reads this gene through one marker. Checked against breeds that visibly have and lack the trait, it does not tell them apart (great dane at 56%), so this page shows no breed frequencies for it.
STC2 as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.
In humans, this gene's counterpart is STC2. That ortholog is what connects STC2 to a century of human medical genetics. The dog and human proteins are 91% identical.
In people, STC2 appears tolerant of loss-of-function variation (gnomAD v4.1 constraint, LOEUF 0.76). Constraint measures intolerance to loss-of-function only and does not indicate importance; some tolerant genes cause disease through other mechanisms.
Lookup and discovery are candidate-framed research surfaces. Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.
Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For STC2 we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.
Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.