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Canine gene

LCORL

Human counterpart: LCORL

LCORL is a gene catalogued in the canine genome. Here is its canonical identity across the genomics world and, where documented, its human counterpart.

Body Size across breeds

LCORL is the NCAPG/LCORL height locus on chromosome 3, one of the strongest single contributors to canine body size.

The atlas reads this gene through one marker. Checked against breeds that visibly have and lack the trait, it does not tell them apart (mastiff at 38%), so this page shows no breed frequencies for it.

In the reference databases

LCORL as it is catalogued across the genomics world. Each link is the canonical record, so this gene composes with everything those resources know.

The human counterpart

In humans, this gene's counterpart is LCORL. That ortholog is what connects LCORL to a century of human medical genetics. The dog and human proteins are 82% identical.

In people, LCORL rarely tolerates loss-of-function variation (gnomAD v4.1 constraint, LOEUF 0.34), a sign it does important, dosage-sensitive work.

Research tools for this gene

Lookup and discovery are candidate-framed research surfaces. Classification renders AVCG grades we cite; Sniff does not score variants with a model of its own.

On the numbers

Per-breed allele frequencies across the atlas are surfaced for the trait loci Sniff has verified a direction-of-effect for. For LCORL we show the cited identity and disease associations, and we would rather show you exactly that than a frequency we cannot yet interpret honestly. See the gene catalog for trait loci with frequency views and every disease-linked gene page.

How to cite this page

Gene identity and disease associations are grounded in OMIA (CC-BY) and the open Sniff Atlas. Full citation formats at sniff.world/cite.

Last updated
Sources: OMIA · Sniff gene crossrefs · Ensembl / NCBI / HGNC · gnomAD v4.1 (Karczewski 2020)