Persistent Müllerian Duct Syndrome (PMDS)
Persistent Müllerian Duct Syndrome (PMDS). Autosomal recessive. Observed in 6 of 266 breeds tested in the Sniff Atlas, with measured carrier frequencies drawn from 242,665 dogs (Donner 2023). Per-dog phenotype outcome depends on penetrance, modifiers, and environment; the carrier frequencies below describe variant prevalence, not disease incidence.
- OMIA identifier
- OMIA:000791-9615
- InheritanceInheritance patternWhat it isHow the condition is passed down: recessive (two copies needed), dominant (one copy), or more complex.For your dogRecessive means a single-copy carrier is usually healthy but can still pass it on.PreciselyThe documented mode of Mendelian transmission (autosomal recessive or dominant, X-linked, etc.) per OMIA.OMIA · documented
- Autosomal recessive
- Source dataset
- Sniff Atlas v1.0.1 / DOI
A model of human persistent Mullerian duct syndrome
This is the canine counterpart of persistent Mullerian duct syndrome in people. That makes affected dogs a naturally-occurring model of the human disease, and it is part of why studying dogs moves medicine forward for everyone. It does not mean your dog has the human disease. It means the two share an underlying biology.
In people, the disease is described as: Persistent Mullerian duct syndrome (PMDS) is a rare disorder of sex development (DSD) characterized by the persistence of Müllerian derivatives, the uterus and/or fallopian tubes, in otherwise normally virilized boys.
In humans it is also called: PMDS, female genital ducts in otherwise normal male, persistent Mullerian derivatives, persistent mullerian duct syndrome, type I, persistent mullerian duct syndrome, type II.
Mapped from OMIA via the human disease's OMIM entry to the Mondo Disease Ontology (Monarch Initiative, CC-BY 4.0). Sniff renders this as a model-of link; the canine disease remains the subject of this page.
From OMIA's curated record
Documented in OMIA (Online Mendelian Inheritance in Animals). This describes the disease as recorded in the published literature, not a prediction for any individual dog. As of 2026-06-03.
Summary
Human analog
OMIA links this condition to its human counterpart in OMIM (Mendelian Inheritance in Man), the place to read across to the deeper human literature for the same biology.
Source: OMIA (Nicholas, Tammen & the Sydney Informatics Hub), entry OMIA:000791-9615, doi:10.25910/2AMR-PV70 (CC-BY 4.0).
How it presents
Catalogued in the Mondo disease ontology (the cross-species disease identity used by the Monarch Initiative) as persistent Mullerian duct syndrome (MONDO:0009857).
Phenotype terms: Human Phenotype Ontology + Mammalian Phenotype Ontology; disease terms: Mondo (Monarch Initiative). Cross-references curated by OMIA (doi:10.25910/2AMR-PV70, CC-BY 4.0).
Published references
The peer-reviewed papers behind this disease, curated by OMIA. Starred entries are OMIA-designated landmark papers. Showing 6 of 25.
- Case report: Persistent Müllerian duct syndrome and enlarged prostatic utricle in a male dog. · Front Vet Sci · 2023 · PMID 37470070
- Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture. · Genome Biol · 2023 · PMID 37582787
- Persistent mullerian duct syndrome in a dog. · Schweiz Arch Tierheilkd · 2023 · PMID 36852872
- A case of persistent Mullerian duct syndrome in a dog. · J Small Anim Pract · 2021 · PMID 33034383
- Persistent Mullerian duct Syndrome in a Brazilian miniature schnauzer dog. · An Acad Bras Cienc · 2019 · PMID 31241703
- Persistent Müllerian duct syndrome in a German shepherd dog. · Sex Dev · 2018 · PMID 30086548
References curated by OMIA (Nicholas, Tammen & the Sydney Informatics Hub), doi:10.25910/2AMR-PV70 (CC-BY 4.0). Full list at the OMIA entry.
Set each parent's status for Persistent Müllerian Duct Syndrome (PMDS) and see the odds for their puppies. Single recessive variant, exact Mendelian math.
These are the genetic odds for one known variant, not a promise: a real litter varies around them, and penetrance or other genes can change whether the condition ever appears. Use it to avoid pairing two carriers and to keep a line healthy, not to engineer a dog. Inheritance mode per OMIA.
See what Persistent Müllerian Duct Syndrome (PMDS) looks like in your dog's breed.
Top 6 well-sampled breeds (n ≥ 50)
Maximum carrier frequencyCarrier frequencyWhat it isHow many dogs in a breed carry one copy of a disease variant, usually without being affected themselves.For your dogA carrier is typically healthy. For most recessive conditions a dog needs two copies to be at risk.PreciselyThe proportion of a population carrying at least one copy of the variant allele. Population prevalence, not disease incidence.Sniff Atlas (Donner 2023) · measured per breed across variants in the Donner 2023 cohort, with Wilson 95% confidence intervalsWilson 95% confidence intervalWhat it isThe range the true frequency is probably in. A wide range means we are less sure, usually because few dogs were tested.For your dogTrust tight ranges; treat wide ones as rough estimates.PreciselyA binomial-proportion confidence interval (Wilson score, 95%) that stays reliable at small sample sizes.Sniff Atlas methodology · statistical. The list below is split into well-sampled breeds (n ≥ 50 tested) and small-sample breeds (n < 50, where the Wilson CI typically spans more than 20 percentage points and frequencies should not be compared directly to the well-sampled entries). Frequencies are population-level, not per-litter or per-line.
▸ Full table with Wilson 95% confidence intervals
| Breed | Carrier frequency | n tested |
|---|---|---|
| Schnauzer Miniature | 9.4% | 4,638 |
| Scottish Terrier | 0.21% | 237 |
| Pembroke Welsh Corgi | <0.1% | 4,371 |
| Chihuahua | <0.1% | 4,273 |
| American Staffordshire Terrier | <0.1% | 42,793 |
| Yorkshire Terrier | <0.1% | 8,367 |
260 additional breeds in the Donner 2023 cohort were tested but showed no carriers.
From genotype to phenotype
Carrier status is not the same as disease status. Penetrance is the fraction of at-risk dogs that develop the phenotype. The Donner 2023 S4 table tracks this for 1 variant(s) underlying this disease in the cohort.
- At-risk dogs evaluated
- 13
- Phenotype confirmed
- 1
- Penetrance range
- not yet quantifiable
Fewer than 20 at-risk dogs evaluated; too few to state a penetrance figure.
Predicted disease relevance at the per-dog level is UNPROVEN. The carrier frequency is measured; phenotype outcome is governed by penetrance, environment, and modifier loci. Consult a veterinarian for clinical interpretation.
Citations
If you use this record in published work, cite the Sniff Atlas (the published dataset that carries the breed-level carrier frequencies) and the upstream sources:
- Sniff Atlas v1.0.1 for the per-breed carrier frequencies:
Gehring, M. (2026). Sniff Atlas v1.0.1. Zenodo. https://doi.org/10.5281/zenodo.20566358. CC-BY 4.0.
- OMIA for the disease definition, inheritance, and gene assignment:
Nicholas, F. W., & Tammen, I. (2024). OMIA. Sydney Informatics Hub, The University of Sydney. https://doi.org/10.25910/2AMR-PV70. Entry: OMIA:000791-9615.
- Donner et al. 2023 for the breed × variant carrier-frequency cohort:
Donner, J., Freyer, J., Davison, S., Anderson, H., Blades, M., Honkanen, L., et al. (2023). Genetic prevalence and clinical relevance of canine Mendelian disease variants in over one million dogs. PLOS Genetics, 19(2), e1010651. https://doi.org/10.1371/journal.pgen.1010651.
Full citation formats (BibTeX, RIS, CITATION.cff) at sniff.world/cite.
Related
- Sniff Atlas v1.0.1, the source dataset for these frequencies.
- Browse breeds, per-breed Mendelian profiles, including this disease in context.
- OMIA entry OMIA:000791-9615, authoritative clinical reference.
- About OMIA, the catalogue this record comes from, and how Sniff uses it.